ABOUT
Host-pathogen interactions
Understanding host-pathogen interactions is at the heart of the fight against pathogens involved in infectious diseases (viruses, bacteria).
RESEARCH GROUPS
Alain Roussel’s group
The studies we conduct focus on one hand on factors of pathogenicity of bacteria and on the other hand on means of response of host organisms. Our projects can be grouped in 2 disciplines which are immunology and microbiology.
Adeline Goulet’s group
Bacteriophages (phages) are the most abundant biological entities on Earth. Yet, these sophisticated bacteria-killing nanomachines remain poorly understood.
What has made them so successful?
Isabelle Imbert’s group
RNA viruses are responsible for all emerging infectious diseases (Ebola, Coronaviruses…). Combining multidisciplinary approaches such as biochemistry, enzymology, structural biology and artificial intelligence methods, we aim to dissect fascinating RNA virus replication machineries.
Philippe Leone’s group
Our objective is to solve the structures of the isolated soluble domains of L and N proteins, and of the L-M and K-L-M-N membrane complexes of T9SS from two bacterial models, by X-ray crystallography and cryo-EM.
JOIN US
We are always looking for talented and motivated research trainees, Ph.D students or post-doctoral fellows so please feel free to contact us.
LATEST PUBLICATIONS
Delauzun V, Amigues B, Gaubert A, Leone P, Grange M, Gauthier L, Roussel A
Genomic and morphological characterization of a novel genus of phages infecting Streptococcus thermophilus. (2020)
Philippe C, Levesque S, Dion MB, Tremblay DM, Horvath P, Lüth N, Cambillau C, Franz C, Neve H, Fremaux C, Heller KJ, Moineau S
Crystal structure of Type IX secretion system PorE C-terminal domain from Porphyromonas gingivalis in complex with a peptidoglycan fragment. (2020)
Trinh NTT, Tran HQ, Van Dong Q, Cambillau C, Roussel A, Leone P
Hardouin P and Goulet A. Biochem Soc Trans PMID: 32196554
Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9 (2020)
Agudelo D, Carter S, Velimirovic M, Duringer A, Levesque S, Rivest JF, Loehr J, Mouchiroud M, Cyr D, Waters PJ, Laplante M, Goulet A, and Doyon Y., Genome Research, 30(1):107-117
Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6. (2019)
Fuchsbauer O, Swuec P, Zimberger C, Amigues B, Levesque S, Agudelo D, Duringer A, Chaves-Sanjuan A, Spinelli S, Rousseau GM, Velimirovic M, Bolognesi M, Roussel A, Cambillau C, Moineau S, Doyon Y, Goulet A. Mol Cell 76 922-937 PMID:31604602
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AFMB – Architecture et Fonction des Macromolécules Biologiques
CNRS – Aix-Marseille Univ. UMR7257
Parc Scientifique et Technologique de Luminy – Case 932
163 avenue de Luminy
13288 Marseille CEDEX 09